The University of Southampton

Rapid COVID-19 diagnostics trials underline potential for daily population testing

Published: 24 September 2020
Illustration
Unique photonics platform used to produce rapid, lab free COVID-19 test

Trials of a new COVID-19 test developed in the Optoelectronics Research Centre (ORC), part of the Zepler Institute for Photonics and Nanoelectronics (ZIPN) have identified an inexpensive route to vastly expand the UK’s testing capacity.

The cheap diagnostic test can detect the presence of the SARS-CoV-2 virus which causes COVID-19 in 10 to 15 minutes.

It is hoped the kits could become an alternative to laboratory-based RT-PCR tests that require one or two days to return a result.

If the product is widely produced it could be rapidly deployed to clinics and GP surgeries as a point-of-care test which would relieve the high demand currently being experienced by PCR testing centres. The low cost of the product could also pave the way for large-scale testing of individuals in schools, airports or businesses.

The University of Southampton's Faculty of Medicine have carried out trials using 150 patient swabs, 125 of which had tested positive with a PCR test and 25 that had tested negative. The results showed the new product can reliably detect COVID-19 in individuals with moderate to high viral levels, the most infectious patients.

Dr Collin Sones, ZIPN project lead, says: “A cheap rapid test such as ours could complement existing tests being used to control the spread of virus. Its key strength is that it can be used at home by anyone, making daily testing of the population an achievable reality. The individuals whose samples were identified as positive by our test would be the ones more likely to spread the disease because of their high viral loads.”

The test involves taking a patient’s nasal swab and mixing it with a solution in a tube. Working in a similar way to the commonly available pregnancy test, a paper strip containing a capture antibody is then dipped into the tube to absorb the solution. As the liquid moves up the strip, a red line will appear if the virus is present in the sample.

The team are now in discussions with manufacturers who would be able to produce the test at scale and begin the process for obtaining the necessary regulatory approvals.

The project received funding from the Engineering and Physical Sciences Research Council's Impact Acceleration Account and the ZIPN Stimulus Fund to progress work to test and develop the product.

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